Insulin Preparations Vary In

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Insulin Preparations Vary In

their time to onset and duration of action:
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1) The onset and duration of action of the insulin preparations is controlled by the size and composition of the crystals in the insulin preparation. 2) Rapid and Intermediate onset and duration; Prolonged duration. 3) The various ways to slow absorption is the inclusion of protamine (NPH insulin), changing the isoelectric point of insulin so it precipitates at site of injection (Insulin glargine) or adding a fatty acid chain, which enhances the association to albumin (Insulin detemir). NPH-Neutral Protamine Hagedorn
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