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What Is The Consequence Of Missing Or Defective Rb Proteins For Cell-Cycle Regulation?

What is the consequence of missing or defective Rb proteins for cell-cycle regulation? E2F is active in the absence of G1 cyclin, resulting in failure of the G1 checkpoint. G1 cyclin is overproduced, resulting in failure of the G1 checkpoint. E2F is inactive in the absence of G1 cyclin, resulting in failure of the G1 checkpoint. E2F is active in the absence of MPF cyclin, resulting in failure of the G2 checkpoint.
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E2F is active in the absence of G1 cyclin, resulting in failure of the G1 checkpoint.
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