Which Of The Following Would Be Unlikely To Contribute To The Substrate Specificity Of An Enzyme?

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Which Of The Following Would Be Unlikely To Contribute To The Substrate Specificity Of An Enzyme?

A hydrophobic group on the substrate interacts with several hydrophobic amino acids on the enzyme. A positive charge on the substrate is attracted to a negative charge in the active site of the enzyme. The enzyme has the ability to change its configuration in response to the substrate binding. A similar shape exists between a pocket on the surface of the enzyme and a functional group on the substrate. The enzyme has an allosteric regulatory site.
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The enzyme has an allosteric regulatory site.

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