What Is The Purpose Of The Sodium Acetate Solution In The Amide Synthesis Of Acetophenetidin

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What Is The Purpose Of The Sodium Acetate Solution In The Amide Synthesis Of Acetophenetidin

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It is used to buffer the reaction mixture because control of acidity is important in maximizing yield. Protonation activates acetic anhydride toward nucleophilic attack, but if the pH is too low the starting amine will will be converted to its conjugate acid.

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