Why Are Chromosomes Cut Into Fragments For Sequencing?

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Why Are Chromosomes Cut Into Fragments For Sequencing?

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DNA sequencing reaction can only accurately determine about 500 bases of DNA. [Scientists adopted a strategy called map-based sequencing, in which the DNA of a cell is cut into relatively large pieces. These large pieces are then cut into smaller fragments that can be sequenced individually and later aligned to produce the full sequence of a chromosome.]

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