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Base Substitution Mutations And Frameshift Mutations

If a segment of DNA were replicated without any errors, the replicated strand would have the following sequence of nucleotides: 5' - ACTACGTGA - 3' Sort the following replicated DNA sequences by the type of point mutation each contains (frameshift, base substitution, or neither), as compared to the correct sequence shown above.
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Sort the items into the appropriate bins. frameshift mutation 5'-ACTCGTGA-3' 5'-ACTTACGTGA-3' base substitution mutation 5'-ACTACGTGT-3' 5'-ACTAAGTGA-3' neither Nothing Correct A base substitution mutation can occur if the DNA polymerase inserts the wrong nucleotide base as it synthesizes a new strand of DNA. A frameshift mutation can occur if the DNA polymerase leaves out a nucleotide or adds an extra nucleotide to the sequence. Certain forms of cancer occur because of mutations in DNA sequences that are located in so-called mutational hotspots. These hotspots are locations in the DNA sequence where mutations occur more often than in other places.
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