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Digoxin And Potassium

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¥Digoxin binds to the Na+-K+-ATPase pump causing inhibition of Na+-K+-ATPase ¥This decreases outward transport of Na+ and leads to increased intracellular Na+ ¥Increased Na+ in the cell, favors Ca++ entry and decreased Ca++ extrusion from the cell (by fooling the Na-Ca transporter) ¥This results in increased intracellular Ca++ leading to increased force of cell contraction

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