The Effectiveness Of Certain Anesthetics Depends In Part On Their Lipid Solubility. Why Is This?

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The Effectiveness Of Certain Anesthetics Depends In Part On Their Lipid Solubility. Why Is This?

Polar substances, such as lipid-soluble drugs, have high solubility. The hydrophobic core of the phospholipid bilayer enables lipid-soluble substances to readily pass through the plasma membrane. The hydrophilic nature of lipid-soluble drugs speeds up their passage through the plasma membrane. Lipid-soluble drugs trigger the opening of certain channels, which they can use to pass through the plasma membrane.
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The hydrophobic core of the phospholipid bilayer enables lipid-soluble substances to readily pass through the plasma membrane.

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