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What Is The Initiating Event That Leads To The Development Of Atherosclerosis?

a. Release of the inflammatory cytokines b. Macrophages adhere to vessel walls. c. Injury to the endothelial cells that line the artery walls d. Release of the platelet-deprived growth factor
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ANS: C Atherosclerosis begins with an injury to the endothelial cells that line the arterial walls. Possible causes of endothelial injury include the common risk factors for atherosclerosis, such as smoking, hypertension, diabetes, increased levels of low-density lipoprotein, decreased levels of high-density lipoprotein, and autoimmunity. The remaining options occur only after the endothelial cells are injured.

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