Which Of The Following Mutations Is Most Likely To Cause A Phenotypic Change?

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Which Of The Following Mutations Is Most Likely To Cause A Phenotypic Change?

A. a large inversion whose ends are each in the same region between genes B. a nucleotide substitution in an exon coding for a transmembrane domain C. a frameshift mutation one codon away from the 3' end of the nontemplate strand D. a duplication of all or most introns E. a single nucleotide deletion in an exon coding for an active site
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E

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